Fluoroquinolones 2nd vs 3rd vs 4th Generation Targets Mechanism of Action

Lesson on the Fluoroquinolone Quinolone antibiotics ciprofloxacin vs.
levofloxacin vs.
moxifloxacin.
Fluoroquinolones include the antibiotics with the suffix -floxacin.
Earlier generations of quinolones have activity against gram negative bacteria whereas later generations have additional activity against gram positive bacteria and anaerobes.
The mechanism of action is similar amongst all fluoroquinolones whereby they target 2 specific bacterial enzymes involved in bacterial DNA synthesis causing DNA damage and bacterial cell death.
Fluoroquinolone use can cause a variety of adverse reactions with some of these reactions preventing their use in children and pregnant women. I hope you find this lesson helpful.
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Источник: rutube.ru